Immunogenicity of modified vaccinia virus Ankara expressing the hemagglutinin stalk domain of pandemic (H1N1) 2009 influenza virus
Identifieur interne : 000296 ( Main/Exploration ); précédent : 000295; suivant : 000297Immunogenicity of modified vaccinia virus Ankara expressing the hemagglutinin stalk domain of pandemic (H1N1) 2009 influenza virus
Auteurs : Giuseppina Di Mario [Italie] ; Elisa Soprana [Italie] ; Francesco Gubinelli [Italie] ; Maddalena Panigada [Italie] ; Marzia Facchini [Italie] ; Concetta Fabiani [Italie] ; Bruno Garulli [Italie] ; Michela Basileo [Italie] ; Antonio Cassone [Italie] ; Antonio Siccardi [Italie] ; Isabella Donatelli [Italie] ; Maria R. Castrucci [Italie]Source :
- Pathogens and Global Health [ 2047-7724 ] ; 2017.
Abstract
Url:
DOI: 10.1080/20477724.2016.1275464
PubMed: 28081672
PubMed Central: 5375617
Affiliations:
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Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Siccardi, Antonio" sort="Siccardi, Antonio" uniqKey="Siccardi A" first="Antonio" last="Siccardi">Antonio Siccardi</name><affiliation wicri:level="3"><nlm:aff id="af2">Molecular Immunology Unit, San Raffaele Research Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Immunology Unit, San Raffaele Research Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28081672</idno><idno type="pmc">5375617</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5375617</idno><idno type="RBID">PMC:5375617</idno><idno type="doi">10.1080/20477724.2016.1275464</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000739</idno><idno type="wicri:Area/Pmc/Curation">000739</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Soprana, Elisa" sort="Soprana, Elisa" uniqKey="Soprana E" first="Elisa" last="Soprana">Elisa Soprana</name><affiliation wicri:level="3"><nlm:aff id="af2">Molecular Immunology Unit, San Raffaele Research Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Immunology Unit, San Raffaele Research Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Gubinelli, Francesco" sort="Gubinelli, Francesco" uniqKey="Gubinelli F" first="Francesco" last="Gubinelli">Francesco Gubinelli</name><affiliation wicri:level="3"><nlm:aff id="af2">Molecular Immunology Unit, San Raffaele Research Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Immunology Unit, San Raffaele Research Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Panigada, Maddalena" sort="Panigada, Maddalena" uniqKey="Panigada M" first="Maddalena" last="Panigada">Maddalena Panigada</name><affiliation wicri:level="3"><nlm:aff id="af2">Molecular Immunology Unit, San Raffaele Research Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Immunology Unit, San Raffaele Research Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Facchini, Marzia" sort="Facchini, Marzia" uniqKey="Facchini M" first="Marzia" last="Facchini">Marzia Facchini</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Fabiani, Concetta" sort="Fabiani, Concetta" uniqKey="Fabiani C" first="Concetta" last="Fabiani">Concetta Fabiani</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Garulli, Bruno" sort="Garulli, Bruno" uniqKey="Garulli B" first="Bruno" last="Garulli">Bruno Garulli</name><affiliation wicri:level="3"><nlm:aff id="af3">Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Basileo, Michela" sort="Basileo, Michela" uniqKey="Basileo M" first="Michela" last="Basileo">Michela Basileo</name><affiliation wicri:level="1"><nlm:aff id="af4">Polo d’Innovazione della Genomica, Genetica e Biologia, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Polo d’Innovazione della Genomica, Genetica e Biologia, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Cassone, Antonio" sort="Cassone, Antonio" uniqKey="Cassone A" first="Antonio" last="Cassone">Antonio Cassone</name><affiliation wicri:level="1"><nlm:aff id="af4">Polo d’Innovazione della Genomica, Genetica e Biologia, University of Perugia, Perugia, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Polo d’Innovazione della Genomica, Genetica e Biologia, University of Perugia, Perugia</wicri:regionArea><wicri:noRegion>Perugia</wicri:noRegion></affiliation></author><author><name sortKey="Siccardi, Antonio" sort="Siccardi, Antonio" uniqKey="Siccardi A" first="Antonio" last="Siccardi">Antonio Siccardi</name><affiliation wicri:level="3"><nlm:aff id="af2">Molecular Immunology Unit, San Raffaele Research Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Molecular Immunology Unit, San Raffaele Research Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><affiliation wicri:level="3"><nlm:aff id="af1">Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Infectious Diseases, Istituto Superiore di Sanità, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Pathogens and Global Health</title><idno type="ISSN">2047-7724</idno><idno type="eISSN">2047-7732</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> Vaccination offers protection against influenza, although current vaccines need to be reformulated each year. The development of a broadly protective influenza vaccine would guarantee the induction of heterosubtypic immunity also against emerging influenza viruses of a novel subtype. Vaccine candidates based on the stalk region of the hemagglutinin (HA) have the potential to induce broad and persistent protection against diverse influenza A viruses.</p><p><bold>Methods:</bold> Modified vaccinia virus Ankara (MVA) expressing a headless HA (hlHA) of A/California/4/09 (CA/09) virus was used as a vaccine to immunize C57BL/6 mice. Specific antibody and cell-mediated immune responses were determined, and challenge experiments were performed by infecting vaccinated mice with CA/09 virus.</p><p><bold>Results</bold>: Immunization of mice with CA/09-derived hlHA, vectored by MVA, was able to elicit influenza-specific broad cross-reactive antibodies and cell-mediated immune responses, but failed to induce neutralizing antibodies and did not protect mice against virus challenge.</p><p><bold>Conclusion</bold>: Although highly immunogenic, our vaccine was unable to induce a protective immunity against influenza. A misfolded and unstable conformation of the hlHA molecule may have affected its capacity of inducing neutralizing antiviral, conformational antibodies. Design of stable hlHA-based immunogens and their delivery by recombinant MVA-based vectors has the potential of improving this promising approach for a universal influenza vaccine.</p></div></front></TEI><affiliations><list><country><li>Italie</li></country><region><li>Latium</li><li>Lombardie</li></region><settlement><li>Milan</li><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Di Mario, Giuseppina" sort="Di Mario, Giuseppina" uniqKey="Di Mario G" first="Giuseppina" last="Di Mario">Giuseppina Di Mario</name></region><name sortKey="Basileo, Michela" sort="Basileo, Michela" uniqKey="Basileo M" first="Michela" last="Basileo">Michela Basileo</name><name sortKey="Cassone, Antonio" sort="Cassone, Antonio" uniqKey="Cassone A" first="Antonio" last="Cassone">Antonio Cassone</name><name sortKey="Castrucci, Maria R" sort="Castrucci, Maria R" uniqKey="Castrucci M" first="Maria R." last="Castrucci">Maria R. Castrucci</name><name sortKey="Donatelli, Isabella" sort="Donatelli, Isabella" uniqKey="Donatelli I" first="Isabella" last="Donatelli">Isabella Donatelli</name><name sortKey="Fabiani, Concetta" sort="Fabiani, Concetta" uniqKey="Fabiani C" first="Concetta" last="Fabiani">Concetta Fabiani</name><name sortKey="Facchini, Marzia" sort="Facchini, Marzia" uniqKey="Facchini M" first="Marzia" last="Facchini">Marzia Facchini</name><name sortKey="Garulli, Bruno" sort="Garulli, Bruno" uniqKey="Garulli B" first="Bruno" last="Garulli">Bruno Garulli</name><name sortKey="Gubinelli, Francesco" sort="Gubinelli, Francesco" uniqKey="Gubinelli F" first="Francesco" last="Gubinelli">Francesco Gubinelli</name><name sortKey="Panigada, Maddalena" sort="Panigada, Maddalena" uniqKey="Panigada M" first="Maddalena" last="Panigada">Maddalena Panigada</name><name sortKey="Siccardi, Antonio" sort="Siccardi, Antonio" uniqKey="Siccardi A" first="Antonio" last="Siccardi">Antonio Siccardi</name><name sortKey="Soprana, Elisa" sort="Soprana, Elisa" uniqKey="Soprana E" first="Elisa" last="Soprana">Elisa Soprana</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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